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Creatine supplementation has been shown to down-regulate the synthesis of l-arginine : glycine amidinotransferase and consequently reduce endogenous formation of creatine, changing the methylation flux and reducing Hcy synthesis ( Reference Taes, Delanghe and De Vriese 6 , Reference Stead, Au and Jacobs 20 )

[49] Stadlbauer S, Steinborn C, Klemd A, et al

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In rat models, GHK-Cu's neuroprotective effects were evident through improved neurological deficits, reduced brain swelling, and inhibition of neuron death

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